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Abstract: The ability of the ocular lens to focus light onto the retina depends on the properties of lens transparency and accommodation. Impairment of these characteristics of the lens leads to development of cataract and presbyopia. The role of actin-binding protein, drebrin, in lens morphogenesis and growth will also be discussed. Rachel Kuperman, EyszTitle: The Eyes are a window into lyer Brain.

Abstract: Epilepsy is a neurological disorder defined by unprovoked seizures, which are treated with anti-epileptic drugs (AEDs). However, while seizures are the defining characteristic of epilepsy, they are not the only symptom for many patients, who often have additional cognitive and behavioral deficits. Eysz is developing a digital therapeutic that uses a consumer grade eye-tracking device in an ambulatory setting to collect a time series of oculometric data, which are analyzed to quantify seizure burden and cognition.

Eysz is currently running a multicenter clinical study partially funded by the NIH to develop a method of identifying seizures based on analysis of spontaneous eye movements. Over the past decade, corneal transplantation procedures have evolved from full-thickness transplantation procedures to selective endothelial keratoplasty procedures to improve intraoperative and postoperative surgical outcomes for patients.

More recent studies have demonstrated the use of rho-associated kinase (ROCK) inhibitors in accelerating corneal endothelial wound healing and potentially providing a new avenue to address these diseases. Collaboration between the veterinary and human medicine ophthalmologists at the UC Davis School of Medicine and UC Davis School of Veterinary Medicine are leading the way in advancing research in this area.

Abstract: Within the retina, photoreceptors are the gateway for vision and are among the primary cells to be affected by retinal disease. Their optical and electrical properties, spatial sampling and spectral topography set the primary constraints on the fidelity of spatial and color vision.

We will describe the basis Iodinated 1-125 Albumin Injection (Jeanatope 1-125)- FDA the technology and discuss how it is being applied to reveal the fundamental properties of the cone photoreceptor mosaic in health and disease. Tim Sweeny, University of DenverTitle: Integration and Segmentation. Abstract: To distill order and meaning from chaos, the visual system leverages at least two broad strategies--integration and segmentation. Integration is everywhere and at all scales.

Individual neurons integration information. So do populations of cells. Integration determines what visual information is related, goes together, and it allows people to make summary or gist-level judgments. Segmentation, on the other hand, exaggerates differences in the visual world. Segmentation prevents the visual Iodinated 1-125 Albumin Injection (Jeanatope 1-125)- FDA from generalizing across sets of things that look different from each other or do not go together, and it allows people to make quick categorical distinctions about objects.

Integration and segmentation appear to be complementary, yet both may occur at the same time, and when they do, they may conflict with one another. Santani Teng, Smith-KettlewellTitle: Iodinated 1-125 Albumin Injection (Jeanatope 1-125)- FDA and distinct mechanisms in blind and sighted reading.

Abstract: Reading is one of the most Iodinated 1-125 Albumin Injection (Jeanatope 1-125)- FDA visual activities. How does it happen without vision. This talk will briefly examine two studies of braille reading in blind adults. In the first study, blind and sighted adults were presented with individual braille and visual alphabetic letters, respectively, during magnetoencephalographic (MEG) reference books. The results suggest that despite spatiotemporally distinct neural responses, the brain dynamics of the two groups include a shared representational structure.

In the second study, blind adults read braille prose paragraphs while their hand positions were recorded. We examined the kinematics and possible perceptual roles of the respective hands in different reading styles, including regressive movements and simultaneous disjoint reading, a putative reading mode using both hands to read text in parallel. These studies highlight possible shared neural mechanisms between reading modalities, as well as distinct modes unique to braille.

Brittany Willams, UNC Chapel HillTitle: Characterization Iodinated 1-125 Albumin Injection (Jeanatope 1-125)- FDA patient-specific mouse models of IMPG2-mediated retinitis pigmentosa. Abstract: Interphotoreceptor matrix proteoglycan 2 (IMPG2) is a proteoglycan that plays an essential role in photoreceptor communication and maintenance. Homozygous missense mutations or deletions in IMPG2 cause retinitis pigmentosa (RP), a common yet debilitating retinal degenerative disease.

Moreover, the disease progression caused by the loss of IMPG2 is unknown. To better understand the pathophysiology caused by the loss of IMPG2, we characterized several mouse models of Iodinated 1-125 Albumin Injection (Jeanatope 1-125)- FDA RP. These mouse models include: an early pediatric surgery mutation (Q244Ter), a patient- modeling point mutation substitution of a tyrosine (Y) to a cysteine (C) at position 250 (Y250C), and a patient-modeling frameshift at pussy creamy 807 resulting in a truncation due to the insertion of a stop codon (T807Ter).

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